A Prion Epigenetic Switch Establishes an Active Chromatin State
نویسندگان
چکیده
منابع مشابه
Breaking an Epigenetic Chromatin Switch: Curious Features of Hysteresis in Saccharomyces cerevisiae Telomeric Silencing
In addition to gene network switches, local epigenetic modifications to DNA and histones play an important role in all-or-none cellular decision-making. Here, we study the dynamical design of a well-characterized epigenetic chromatin switch: the yeast SIR system, in order to understand the origin of the stability of epigenetic states. We study hysteresis in this system by perturbing it with a h...
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Synopsis Despite the tremendous advances in human genetics enabled by the original public and private human genome projects and brought to fruition with high throughput genotyping and " Nextgen " DNA sequencing, many aspects of human biology still cannot be adequately explained by genetics alone. Normal human development requires the specification of a multitude of cell types/organs that depend...
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ژورنال
عنوان ژورنال: Cell
سال: 2020
ISSN: 0092-8674
DOI: 10.1016/j.cell.2020.02.014